Dymatize ISO100 Whey Isolate vs Optimum Nutrition Gold Standard Pro Gainer
Two of our picks from Best Protein Powders, compared side by side on the specs and trade-offs that actually matter.
Short answer
Between the Optimum Nutrition Gold Standard Pro Gainer and the Dymatize ISO100 Whey Isolate, we recommend the Optimum Nutrition Gold Standard Pro Gainer ($144.99 when we checked it on 2026-10-12) as the better protein powder for most people. Hard gainers trying to put on size The Dymatize ISO100 Whey Isolate ($144.09 when we checked it on 2026-10-12) still makes sense if lean macros and fast post-workout recovery.

Dymatize ISO100 Whey Protein Powder Isolate, Fudge Brownie, 25g of Protein, 5 Pound, 5.5g BCAAs, Less Than 120 Cal., Gluten Free, 1g Fat, 1g Sugar, 2g Carb (70 Servings)
$144.09observed
Lowest we have recorded: $106.99 on (18 weekly checks)

Optimum Nutrition Gold Standard Pro Gainer, Weight Gainer Protein Powder, Double Chocolate, 10.19 Pounds (Packaging May Vary)
$144.99observed
Lowest we have recorded: $94.40 on (18 weekly checks)
Specs head to head
| Spec | Dymatize ISO100 Whey Isolate | Optimum Nutrition Gold Standard Pro Gainer |
|---|---|---|
| Protein | 25g per serving | 60g per serving |
Our take on each
Dymatize ISO100 Whey Isolate
Best for: Lean macros and fast post-workout recovery
ISO100 is the pick when you want protein and not much else cluttering the label. Each serving delivers 25g of protein alongside 5.5g of BCAAs, including 2.7g of L-Leucine, while keeping things tight at 1g fat, 1g sugar, and under 120 calories, numbers that are hard to match once you start comparing tubs side by side.
It is filtered to cut excess lactose and carbs, and the protein itself is broken down into small peptides for faster absorption, exactly why people reach for it right after a workout rather than saving it for later in the day. Dymatize publishes third-party Informed-Choice testing on ISO100, which is the check that matters for anyone who gets drug tested.
The tradeoffs are the ones you would expect from a premium isolate. It carries a premium price per tub, and being whey-based, it is not an option if you are following a plant-based diet. For anyone watching macros closely, it is about as clean as protein powder gets.
Optimum Nutrition Gold Standard Pro Gainer
Best for: Hard gainers trying to put on size
Pro Gainer is built for one job: helping you eat more without choking down extra meals throughout the day. Each serving stacks 650 calories, 60g of protein, and more than 80g of carbs, which is the kind of math that actually moves the scale for someone who struggles to eat in a surplus.
It comes from Optimum Nutrition's Gold Standard line, so the brand pedigree behind the formula is well established, and for a genuine hard gainer, someone who trains hard but cannot out-eat their metabolism, this solves a real problem that whole food alone often does not.
Be clear-eyed about who this is for, though. This is not a powder for someone trying to lean out, the calories and carbs are the entire point, not a side effect, so using it while cutting works directly against your goal. It also carries the highest price of the three picks here. For skinny lifters trying to bulk, it does exactly what it promises.
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